The influence of oxygen deprivation and donor age on the effect of statins on human mesenchymal stromal cells
D Sienko, D Klimczak-Tomaniak, A Kulesza… - Tissue and Cell, 2020 - Elsevier
To date, no study evaluated the effect of oxygen deprivation together with statins
pretreatment on human mesenchymal stromal cells (MSCs). The aim of our study was to
establish the influence of atorvastatin and rosuvastatin on MSC proliferation and cytotoxicity
in different oxygenic conditions. Human MSCs isolated from the bone marrow (n= 12) were
incubated with statins. The proliferation rate and cytotoxic effect were evaluated in normoxic
(21% O 2) and hypoxic (2% O 2) conditions, also in relation to donor age. The treatment with …
pretreatment on human mesenchymal stromal cells (MSCs). The aim of our study was to
establish the influence of atorvastatin and rosuvastatin on MSC proliferation and cytotoxicity
in different oxygenic conditions. Human MSCs isolated from the bone marrow (n= 12) were
incubated with statins. The proliferation rate and cytotoxic effect were evaluated in normoxic
(21% O 2) and hypoxic (2% O 2) conditions, also in relation to donor age. The treatment with …
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