The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export
RNA export factor (REF) is a component of the exon junction complex (EJC) that is
deposited on mRNA in a splicing-dependent manner, and targets spliced mRNA for export.
In this study, analysis of the RNA-binding protein complexes revealed that REF associates
with β-globin mRNA at the region other than the EJC deposition site. Comparison between
RNA polymerase II and T7 transcription and further analysis showed that the deposition of
REF apart from the EJC is dependent on the 5′ cap structure, but not splicing. Excess …
deposited on mRNA in a splicing-dependent manner, and targets spliced mRNA for export.
In this study, analysis of the RNA-binding protein complexes revealed that REF associates
with β-globin mRNA at the region other than the EJC deposition site. Comparison between
RNA polymerase II and T7 transcription and further analysis showed that the deposition of
REF apart from the EJC is dependent on the 5′ cap structure, but not splicing. Excess …
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