The lactate paradox in human high-altitude physiological performance

PW Hochachka, CL Beatty, Y Burelle… - …, 2002 - journals.physiology.org
PW Hochachka, CL Beatty, Y Burelle, ME Trump, DC McKenzie, GO Matheson
Physiology, 2002journals.physiology.org
For many years, physiologists have puzzled over the observation that, during maximum
aerobic exercise, high-altitude natives generate lower-than-expected amounts of lactate; the
higher the altitude, the lower the postexercise blood lactate peak. This paradoxical situation
may be caused mainly by upregulated metabolic control contributions from cell ATP demand
and ATP supply pathways.
For many years, physiologists have puzzled over the observation that, during maximum aerobic exercise, high-altitude natives generate lower-than-expected amounts of lactate; the higher the altitude, the lower the postexercise blood lactate peak. This paradoxical situation may be caused mainly by upregulated metabolic control contributions from cell ATP demand and ATP supply pathways.
American Physiological Society
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