Simple Summary Too many women still die of breast cancer each year. Those breast
cancers that kill are those with cells that have migrated away from the primary tumor in the
breast and established new tumors at other sites in the body. These tumors are not reached
when the original tumor in the breast is removed. This study was designed to determine why
some breast cancers move away from their primary tumor and others do not. We have
identified a protein that inhibits this movement. Understanding this finding may provide us …

Breast cancer is the most common cancer in women. Despite advances in early detection
and treatment, it is predicted that over 40,000 women will die of breast cancer in 2019. This
number of women is still too high. To lower this number, more information about the
molecular players in breast cancer are needed. Several members of the Guanylate-Binding
Proteins (GBPs) have been correlated with better prognosis in breast cancer. In this study,
we asked if the expression of GBP-2 in breast cancer merely provided a biomarker for …