过去一年中添加的文章,按日期排序

Discovery of an anti-malarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function …

A Kimishima, A Nishitomi, I Tsuruoka… - Bioscience …, 2024 - academic.oup.com
3 天前 - … the mechanism of action of 1 … -malarial drug discovery platform based on mitochondrial
function inhibitory activity. We evaluated anti-malarial activity and 1 showed anti-malarial

Updated review on the value of natural products in drug discovery in the last decade (2015-2024): Part I

S Abaza - Parasitologists United Journal, 2024 - journals.ekb.eg
6 天前 - … of resistant strains. The clinical significance of natural product was awarded by
identifying new mechanisms of action … treating severely diseases such as malaria, leishmaniasis, …

Mutation of the Plasmodium falciparum Flavokinase Confers Resistance to Roseoflavin and 8-Aminoriboflavin

A Hemasa, C Spry, M Mack, KJ Saliba - ACS Infectious Diseases, 2024 - ACS Publications
16 天前 - … 8-aminoriboflavin, inhibit malaria parasite proliferation by … their mechanism of
action, we generated roseoflavin-resistant … 4-fold resistant to roseoflavin and cross-resistant to 8-…

[HTML][HTML] Evaluation of MMV Pandemic Response Box compounds to identify potent compounds against clinically relevant bacterial and fungal clinical isolates in vitro

S Sivasankar, A Boppe, MP Grobusch… - New Microbes and New …, 2024 - Elsevier
22 天前 - … We set out to test the Pandemic Box compounds from Medicines for Malaria Venture
(MMV) against multi drug-resistant(MDR) A. baumannii and P. aeruginosa bacterial clinical …

Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum

RM Mobley - 2024 - keele-repository.worktribe.com
22 天前 - Malaria continues to cause great global health concerns … resistance to components
of the frontline artemisinin combination therapy highlights the urgent need for novel malaria

Plasmodium falciparum: Transporter and Drug Target

A Aslam, MO Alkurbi, S Alghamdi, Q Aalm - Drug Targets for Plasmodium …, 2024 - Springer
23 天前 - drugs, their modes of binding and site of action, mechanism of action, ways to avoid
a putative resistance … animal malaria models are still matter of debate in scientific fraternity. …

Antimalarial activity of cecropin antimicrobial peptides derived from Anopheles mosquitoes

J Lou, D Zhang, J Wu, G Zhu, M Zhang… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
28 天前 - … -resistant strain 803, and the chloroquine-resistant strain Dd2 in vitro. We also
demonstrate its anti-parasite activity in vivo, using the rodent malaria … its mechanism of action may …

To quest new targets of Plasmodium parasite and their potential inhibitors to combat antimalarial drug resistance

P Biswas, R Roy, K Ghosh, D Nath, A Samadder… - Journal of Parasitic …, 2024 - Springer
42 天前 - … now in use within the malaria parasite have an unclear mechanism of action.
Furthermore, for the majority of medications, the mechanism of resistance is poorly understood (…

Effect of hydroquinine against pathogenic microorganisms and its mechanism

N Rattanachak, J Jongjitwimol - 2024 - nuir.lib.nu.ac.th
46 天前 - … quinine-derivative drugs known to possess anti-malarial activity. … Further, the exact
mechanism of hydroquinine action … has uncovered the mechanism of action of hydroquinine …

Ivermectin resistance mechanisms in ectoparasites: a scoping review

J Furnival-Adams, C Kiuru, AB Sagna, K Mouline… - Parasitology …, 2024 - Springer
50 天前 - … Ivermectin mass drug administration has been used for decades to target human and
… use against malaria vectors. Although there have been few reports of resistance to date in …