The metabolomic-gut-clinical axis of Mankai plant-derived dietary polyphenols
Background: Polyphenols are secondary metabolites produced by plants to defend
themselves from environmental stressors. We explored the effect of Wolffia globosa 'Mankai',
a novel cultivated strain of a polyphenol-rich aquatic plant, on the metabolomic-gut clinical
axis in vitro, in-vivo and in a clinical trial. Methods: We used mass-spectrometry-based
metabolomics methods from three laboratories to detect Mankai phenolic metabolites and
examined predicted functional pathways in a Mankai artificial-gut bioreactor. Plasma and …
themselves from environmental stressors. We explored the effect of Wolffia globosa 'Mankai',
a novel cultivated strain of a polyphenol-rich aquatic plant, on the metabolomic-gut clinical
axis in vitro, in-vivo and in a clinical trial. Methods: We used mass-spectrometry-based
metabolomics methods from three laboratories to detect Mankai phenolic metabolites and
examined predicted functional pathways in a Mankai artificial-gut bioreactor. Plasma and …
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