The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells
Y Akgul, RC Derk, T Meighan, KMK Rao… - Reproductive …, 2008 - Elsevier
Exposure to the pesticide methoxychlor in rodents is linked to impaired steroid production,
ovarian atrophy and reduced fertility. Following in vivo administration, it is rapidly converted
by the liver to 2, 2-bis-(p-hydroxyphenyl)-1, 1, 1-trichloroethane (HPTE), the reported active
metabolite. Both methoxychlor and HPTE have weak estrogenic and antiandrogenic
activities, and these effects are thought to be mediated through the estrogen and androgen
receptors, respectively. Previous in vivo studies on methoxychlor exposure to female …
ovarian atrophy and reduced fertility. Following in vivo administration, it is rapidly converted
by the liver to 2, 2-bis-(p-hydroxyphenyl)-1, 1, 1-trichloroethane (HPTE), the reported active
metabolite. Both methoxychlor and HPTE have weak estrogenic and antiandrogenic
activities, and these effects are thought to be mediated through the estrogen and androgen
receptors, respectively. Previous in vivo studies on methoxychlor exposure to female …
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