The nanopore mass spectrometer

J Bush, W Maulbetsch, M Lepoitevin… - Review of Scientific …, 2017 - pubs.aip.org
We report the design of a mass spectrometer featuring an ion source that delivers ions directly
into high vacuum from liquid inside a capillary with a sub-micrometer-diameter tip. The

Theory for polymer analysis using nanopore-based single-molecule mass spectrometry

JE Reiner, JJ Kasianowicz, BJ Nablo… - Proceedings of the …, 2010 - National Acad Sciences
the PEG position in the nanopore (γ = 0.5 for PEG at the center of the nanopore) (45), and
is the ratio of the electroosmotically induced viscous force to the applied electric force on a …

Single-molecule mass spectrometry in solution using a solitary nanopore

JWF Robertson, CG Rodrigues… - Proceedings of the …, 2007 - National Acad Sciences
… method for mass spectrometry in solution that is based on the … hemolysin pore cause distinct
mass-dependent conductance … The conductance-based mass spectrum clearly resolves the

Solid-state nanopore time-of-flight mass spectrometer

M Tsutsui, K Yokota, A Arima, Y He, T Kawai - ACS sensors, 2019 - ACS Publications
… inside the channel and excludes the ions there, (11) the ion … motions of objects outside the
nanopore in the course of their … the nanopore method can be actually used to detect mass of …

Toward nanopore electrospray mass spectrometry: nanopore effects in the analysis of bacteria

Y Zhang, Y Tang, C Tan, W Xu - ACS Central Science, 2020 - ACS Publications
The feasibility of combining nanopore electrospray with mass spectrometry was explored in
this study. A nanopore effect was observed during the nano-electrospray of single bacterium, …

Nanopore-based single-molecule mass spectrometry on a lipid membrane microarray

G Baaken, N Ankri, AK Schuler, J Ruhe, JC Behrends - Acs Nano, 2011 - ACS Publications
… resolution for single-molecule nanopore-based mass spectroscopy, the specific aim of this
study … nanopores on an array. In particular, we wished to perform a parallel mass spectrometry

Beyond mass spectrometry, the next step in proteomics

W Timp, G Timp - Science Advances, 2020 - science.org
… In particular, long-read sequencing with a nanopore allows for easy resolution of the transcripts
without reconstruction; our work (65, 66) and others (68, 92) suggest that there are many …

The Nanopore Mass Spectrometer

M Lepoitevin, W Maulbetsch, B Wiener, D Stein - Biophysical Journal, 2018 - cell.com
… Our approach merges the ability of nanopores to force polymers to trans… the ability of mass
spectrometry (MS) to identify individual amino acids (AA). The nanopore in our setup takes the

Protein identification by nanopore peptide profiling

FLR Lucas, RCA Versloot, L Yakovlieva… - Nature …, 2021 - nature.com
… In order to compare mass spectrometry and nanopore analysis, we converted the ESI-MS
measurement into an expected I ex,MS % spectrum using an ad-hoc algorithm (Fig. 2e). Each …

Combining Nanopore direct RNA sequencing with genetics and mass spectrometry for analysis of T-loop base modifications across 42 yeast tRNA isoacceptors< …

EA Shaw, NK Thomas, JD Jones… - Nucleic Acids …, 2024 - academic.oup.com
… Here we advance the use of Nanopore direct RNA-sequencing (DRS) to investigate … some
changes in the mass spectrometry analysis of trm6Δ cells could be confounded by the greatly …