[HTML][HTML] The pH of chemistry assays plays an important role in monoclonal immunoglobulin interferences
MO Alberti, TA Drake, L Song - Practical Laboratory Medicine, 2015 - Elsevier
Objectives Immunoglobulin paraproteins can interfere with multiple chemistry assays. We
want to investigate the mechanisms of immunoglobulin interference. Design and methods
Serum samples containing paraproteins from the index patient and eight additional patients
were used to investigate the interference with the creatinine and total protein assays on the
Beckman Coulter AU5400/2700 analyzer, and to determine the effects of pH and ionic
strength on the precipitation of different immunoglobulins in these patient samples. Results …
want to investigate the mechanisms of immunoglobulin interference. Design and methods
Serum samples containing paraproteins from the index patient and eight additional patients
were used to investigate the interference with the creatinine and total protein assays on the
Beckman Coulter AU5400/2700 analyzer, and to determine the effects of pH and ionic
strength on the precipitation of different immunoglobulins in these patient samples. Results …
[PDF][PDF] The pH of chemistry assays plays an important role in monoclonal
MO Alberti, TA Drake, L Song - 2015 - cyberleninka.org
Objectives: Immunoglobulin paraproteins can interfere with multiple chemistry assays. We
want to investigate the mechanisms of immunoglobulin interference. Design & Methods:
Plasma samples containing paraproteins from the index patient and eight additional patients
were used to investigate the interference with the creatinine and total protein assays on the
Beckman Coulter AU5400/2700 analyzer, and to determine the effects of pH and ionic
strength on the precipitation of different immunoglobulins in these patient samples. Results …
want to investigate the mechanisms of immunoglobulin interference. Design & Methods:
Plasma samples containing paraproteins from the index patient and eight additional patients
were used to investigate the interference with the creatinine and total protein assays on the
Beckman Coulter AU5400/2700 analyzer, and to determine the effects of pH and ionic
strength on the precipitation of different immunoglobulins in these patient samples. Results …
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