The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro

B Cevatemre, B Botta, M Mori, S Berardozzi… - Chemico-Biological …, 2016 - Elsevier
Despite the rapid advances in chemotherapy regimens, the outcome of patients with breast
cancer is not satisfactory. One of the reasons of this dissatisfaction is that subsets of cells in
tumors which referred as cancer stem cells (CSCs) show and/or gain resistance to therapies.
Thus, compounds that target CSCs are urgently needed. Since some are already used in the
clinic, natural products have great potential for further development as anti cancer drugs.
The aim of this study is to investigate the cytotoxic activity of tingenin b (or 22β …

The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro

B Botta, M Mori, S Berardozzi, C Ingallina - 2016 - acikerisim.uludag.edu.tr
Despite the rapid advances in chemotherapy regimens, the outcome of patients with breast
cancer is not satisfactory. One of the reasons of this dissatisfaction is that subsets of cells in
tumors which referred as cancer stem cells (CSCs) show and/or gain resistance to therapies.
Thus, compounds that target CSCs are urgently needed. Since some are already used in the
clinic, natural products have great potential for further development as anti cancer drugs.
The aim of this study is to investigate the cytotoxic activity of tingenin b (or 22 beta …
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