[HTML][HTML] The point mutation of the cholesterol trafficking membrane protein NPC1 may affect its proper function in more than a single step: molecular dynamics …
Abstract The Niemann-Pick type C1 (NPC1) protein is one of the key players of cholesterol
trafficking from the lysosome and its function is closely coupled with the Niemann-Pick type
C2 (NPC2) protein. The dysfunction of one of these proteins can cause problems in the
overall cholesterol homeostasis and leads to a disease, which is called the Niemann-Pick
type C (NPC) disease. The parts of the cholesterol transport mechanism by NPC1 have
begun to recently emerge, especially after the full-length NPC1 structure was determined …
trafficking from the lysosome and its function is closely coupled with the Niemann-Pick type
C2 (NPC2) protein. The dysfunction of one of these proteins can cause problems in the
overall cholesterol homeostasis and leads to a disease, which is called the Niemann-Pick
type C (NPC) disease. The parts of the cholesterol transport mechanism by NPC1 have
begun to recently emerge, especially after the full-length NPC1 structure was determined …
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