The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment
M Farhad, AS Rolig, WL Redmond - Oncoimmunology, 2018 - Taylor & Francis
The efficacy of cancer immunotherapy is limited, in part, by the multitude of
immunosuppressive mechanisms present within the tumor microenvironment (TME).
Galectin-3 (Gal-3) is a lectin that contributes to TME immunosuppression and regulates
diverse functions including cellular homeostasis and cancer biology. Increased Gal-3
expression during cancer progression augments tumor growth, invasiveness, metastatic
potential, and immune suppression, which highlights the potential use of Gal-3 as a …
immunosuppressive mechanisms present within the tumor microenvironment (TME).
Galectin-3 (Gal-3) is a lectin that contributes to TME immunosuppression and regulates
diverse functions including cellular homeostasis and cancer biology. Increased Gal-3
expression during cancer progression augments tumor growth, invasiveness, metastatic
potential, and immune suppression, which highlights the potential use of Gal-3 as a …
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