The role of NF-κB signaling pathway in polyhexamethylene guanidine phosphate induced inflammatory response in mouse macrophage RAW264. 7 cells
HR Kim, KH Chung - Toxicology letters, 2015 - Elsevier
Polyhexamethylene guanidine (PHMG) phosphate is a competitive disinfectant with strong
antibacterial activity. However, epidemiologists revealed that inhaled PHMG-phosphate may
increase the risk of pulmonary fibrosis associated with inflammation, resulting in the deaths
of many people, including infants and pregnant women. In addition, in vitro and in vivo
studies reported the inflammatory effects of PHMG-phosphate. Therefore, the aim of the
present study was to clarify the inflammatory effects and its mechanism induced by PHMG …
antibacterial activity. However, epidemiologists revealed that inhaled PHMG-phosphate may
increase the risk of pulmonary fibrosis associated with inflammation, resulting in the deaths
of many people, including infants and pregnant women. In addition, in vitro and in vivo
studies reported the inflammatory effects of PHMG-phosphate. Therefore, the aim of the
present study was to clarify the inflammatory effects and its mechanism induced by PHMG …
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