Multidrug resistance (MDR) remains a major obstacle towards curative treatment of cancer.
Despite considerable progress in delineating the basis of intrinsic and acquired MDR, the
underlying molecular mechanisms remain to be elucidated. Emerging evidences suggest
that dysregulation in endolysosomal compartments is involved in mediating MDR through
multiple mechanisms, such as alterations in endosomes, lysosomes and autophagosomes,
that traffic and biodegrade the molecular cargo through macropinocytosis, autophagy and …