The role of epigenetic mechanisms in B cell lymphoma pathogenesis

L Venturutti, AM Melnick - Annual Review of Cancer Biology, 2021 - annualreviews.org
The capacity of the adaptive immune system to respond to antigenic challenges relies on
rapid diversification, expansion, and functional specialization of mature B cells. To
accomplish this, activated B cells are transiently endowed with phenotypes that would
normally be suppressed in somatic cells, such as enhanced proliferative potential and
tolerance for genomic instability. Acquisition of these traits, directed by immune signaling
cues and orchestrated by transcriptional and epigenetic programs, sets the stage for …
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