The role of glycolysis-derived hexose phosphates in the induction of the Crabtree effect
MR Lemus, E Roussarie, N Hammad… - Journal of Biological …, 2018 - ASBMB
Evidence for the Crabtree effect was first reported by H. Crabtree in 1929 and is defined as
the glucose-induced decrease of cellular respiratory flux. This effect was observed in tumor
cells and was not detected in most non-tumor cells. A number of hypotheses on the
mechanism underlying the Crabtree effect have been formulated. However, to this day, no
consensual mechanism for this effect has been described. In a previous study on isolated
mitochondria, we have proposed that fructose-1, 6-bisphosphate (F1, 6bP), which inhibits …
the glucose-induced decrease of cellular respiratory flux. This effect was observed in tumor
cells and was not detected in most non-tumor cells. A number of hypotheses on the
mechanism underlying the Crabtree effect have been formulated. However, to this day, no
consensual mechanism for this effect has been described. In a previous study on isolated
mitochondria, we have proposed that fructose-1, 6-bisphosphate (F1, 6bP), which inhibits …
[PDF][PDF] The role of glycolysis-derived hexose phosphates in the induction of the Crabtree effect Mónica Rosas Lemus*, Elodie Roussarie*, Noureddine Hammad …
MR Lemus - researchgate.net
Evidence for the Crabtree effect was first reported by H. Crabtree in 1929 and is defined as
the glucose-induced decrease of cellular respiratory flux. This effect was observed in tumor
cells and was not detected in most non-tumor cells. A number of hypotheses on the
mechanism underlying the Crabtree effect have been formulated. However, to this day, no
consensual mechanism for this effect has been described. In a previous study on isolated
mitochondria, we have proposed that fructose-1, 6-bisphosphate (F1, 6bP), which inhibits …
the glucose-induced decrease of cellular respiratory flux. This effect was observed in tumor
cells and was not detected in most non-tumor cells. A number of hypotheses on the
mechanism underlying the Crabtree effect have been formulated. However, to this day, no
consensual mechanism for this effect has been described. In a previous study on isolated
mitochondria, we have proposed that fructose-1, 6-bisphosphate (F1, 6bP), which inhibits …
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