… of tau, which are pivotal in defining and modulating tau localisation and its roles in health
and disease… We include discussion of other pathologically relevant changes in tau, including …

… Tau protein with its extensive pathological role in several neurodegenerative diseases can
be … The abnormal hyperphosphorylation of tau plays detrimental pathological functions which …

… is Alzheimer's disease. The purpose of this review is to define the role of tau protein under
normal physiological conditions and to highlight the role of the protein in different tauopathies. …

… to tau proteins that contain either three (3R) or four (4R) C-terminal microtubule-binding
domains, with 3R tau isoforms binding the microtubules less tightly than 4R tau [12]. Hence, six …

… neurological disorders. The discovery that dominant mutations in the MAPT gene encoding
tau … strongly supports abnormal tau protein as directly involved in disease pathogenesis. This …

… Normal tau biology and functions Tau proteins are low Mr microtuble associated proteins
(MAPs) that are expressed predominantly in axons of central nervous system (CNS) neurons, …

… of tau in the form of neurofibrillary tangles. While the role of tau in Parkinson's disease
has … evidence supporting a role for tau in the pathogenesis of Parkinson's disease. Toxic …

… that characterize these diseases. The exact role of the tau protein in the neurodegenerative
… normal biological roles of tau and the specific events that induce tau to become neurotoxic. …

… of the role of Tau in health and disease hence is crucial to … inhibit its pathological role leaving
its physiological role (relatively… Tau protein is a natively unfolded protein with a remarkably …

… tau protein have been reported to be the underlying cause of a group of neurodegenerative
disorders … The detrimental consequence is the loss of affinity between this protein and the …