To determine the role of vascular cell adhesion molecule 1 (VCAM-1)/very late activation
antigen 4 (VLA-4) and intercellular adhesion molecule 1 (ICAM-1)/lymphocyte function-
associated antigen 1 (LFA-1) interactions in causing antigen-induced eosinophil and T cell
recruitment into the tissue, we studied the effect of the in vivo blocking of VCAM-1, ICAM-1,
VLA-4, and LFA-1 by pretreatment with monoclonal antibodies (mAb) to these four adhesion
molecules on the eosinophil and T cell infiltration of the trachea induced by antigen …

Objective Marrow‐derived endothelial progenitor cells (EPCs) are important in the
neovascularization that occurs in diverse conditions such as cardiovascular disorders,
inflammatory diseases, and neoplasms. In rheumatoid arthritis (RA), synovial
neovascularization propels disease by nourishing the inflamed and hyperproliferative
synovium. This study was undertaken to investigate the hypothesis that EPCs selectively
home to inflamed joint tissue and may perpetuate synovial neovascularization. Methods In a …