5 天前 - … (3D) organization of the human genome plays a crucial role in gene regulation. …
regulation, aiming to advance our understanding of the genome’s spatial organization …

5 天前 - … signaling in space and time is vital for self-organization 4 in tissue patterning.
During vertebrate development, the segmentation clock drives 5 oscillatory gene expression in …

5 天前 - … 3D chromatin organization is a fundamental aspect of cellular biology that has … for
gene regulation and cellular function. In this study, we investigated 3D chromatin organization …

6 天前 - … anchoring protein (AKAP)-dependent organization of signaling pathways within
distinct subcellular domains. This spatial organization is also critical for translating electrical …

6 天前 - … DNA-FISH to examine the spatial context of such gene activations. We also explore
the … spatial proximity, loop extrusion, and TAD boundaries, in developmental gene regulation…

7 天前 - … Abstract The spatial organization of chromatin is fundamental to gene regulation
and essential for proper cellular function. The Hi-C technique remains the leading method for …

9 天前 - … spatial organization of transcriptomic profiles by providing evidence that hippocampal
subregions undergo distinct differential gene … and transcriptional regulation. Among these …

9 天前 - … We also analyzed public single-cell RNAseq and spatial metabolomics data 5 to
further … Differential gene expression analysis allowed to define GABA signatures significantly …

9 天前 - … Results Unsupervised learning of the spatial transcriptomics data generated a
TLS-specific spatial gene expression signature that significantly correlates with higher overall …

9 天前 - … These regulons were enriched for cytokine and interleukin signaling in the TME
ROIs (FDR <0.05), cancer induced senescence and TP53 gene regulation in the Mutated ROIs (…