Neurodegeneration observed in Alzheimer disease (AD) is believed to be related to the
toxicity from reactive oxygen species (ROS) produced in the brain by the amyloid-β (Aβ)
protein bound primarily to copper ions. The evidence for an oxidative stress role of Aβ-Cu
redox chemistry is still incomplete. Details of the copper binding site in Aβ may be critical to
the etiology of AD. Here we present the structure determined by combining x-ray absorption
spectroscopy (XAS) and density functional theory analysis of Aβ peptides complexed with …

The structure of the amyloid β-peptide high-affinity copper(II)-binding site in Alzheimer's
disease - NASA/ADS … The structure of the amyloid β-peptide high-affinity copper(II)-binding
site in Alzheimer's disease …