Jdp2 is an AP-1 family transcription factor that regulates the epigenetic status of histones.
Previous in vitro studies revealed that Jdp2 is involved in osteoclastogenesis. However, the
roles of Jdp2 in vivo and its pleiotropic functions are largely unknown. Here we generated
Jdp2–/–mice and discovered its crucial roles not only in bone metabolism but also in
differentiation of neutrophils. Jdp2–/–mice exhibited osteopetrosis resulting from impaired
osteoclastogenesis. Jdp2–/–neutrophils were morphologically normal but had impaired …

CiNii 博士論文 - The transcription factor Jdp2 controls bone homeostasis and antibacterial
immunity by regulating osteoclast and neutrophil differentiation … The transcription factor
Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and
neutrophil differentiation 転写因子Jdp2は骨恒常性と細菌感染防御を破骨細胞と好中球の分化を
制御することで調節する … 転写因子Jdp2は骨恒常性と細菌感染防御を破骨細胞と好中球の分化
を制御することで調節する …