trials (RCTs) from 1998 to 2016 in Pubmed, Web of science and Google scholar. We
evaluated clinical outcomes, comparing postoperative pain scores, cumulative analgesic
consumption, time to first analgesia, and adverse effects between orthopedic surgery
patients with and without the administration of MgSO 4. Results: After screening 2350
articles, 11 RCTs (with a total sample size of 535 subjects) were included in this systematic …