The use of polymer heteronuclei for crystalline polymorph selection
M Lang, AL Grzesiak, AJ Matzger - Journal of the American …, 2002 - ACS Publications
M Lang, AL Grzesiak, AJ Matzger
Journal of the American Chemical Society, 2002•ACS PublicationsA method for the production of crystalline polymorphs from solution is described which
utilizes a diverse set of polymer heteronuclei. Application to crystalline polymorph selection
for the important pharmaceuticals acetaminophen and carbamazepine is demonstrated. This
method provides a new paradigm for polymorph selection, where solvent and temperature
conditions can be chosen on the basis of process considerations and the polymer
heteronucleus can be varied for specific polymorph production.
utilizes a diverse set of polymer heteronuclei. Application to crystalline polymorph selection
for the important pharmaceuticals acetaminophen and carbamazepine is demonstrated. This
method provides a new paradigm for polymorph selection, where solvent and temperature
conditions can be chosen on the basis of process considerations and the polymer
heteronucleus can be varied for specific polymorph production.
A method for the production of crystalline polymorphs from solution is described which utilizes a diverse set of polymer heteronuclei. Application to crystalline polymorph selection for the important pharmaceuticals acetaminophen and carbamazepine is demonstrated. This method provides a new paradigm for polymorph selection, where solvent and temperature conditions can be chosen on the basis of process considerations and the polymer heteronucleus can be varied for specific polymorph production.
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