[HTML][HTML] Thieno [2, 3-d] pyrimidine based derivatives as kinase inhibitors and anticancer agents
EZ Elrazaz, RAT Serya, NSM Ismail… - Future Journal of …, 2015 - Elsevier
EZ Elrazaz, RAT Serya, NSM Ismail, DA Abou El Ella, KAM Abouzid
Future Journal of Pharmaceutical Sciences, 2015•ElsevierThienopyrimidines are fused heterocyclic ring systems; structurally resemble purines,
exerting pharmacological potential in different aspects. They are known to play a crucial role
in various disease conditions. Thieno [2, 3-d] pyrimidine derivatives have been explored for
their inhibitory activities towards various protein kinase enzymes. The present review is a
compilation on chemical synthesis and biological anticancer significance, via inhibition of
specific protein kinase enzymes, including structure–activity relationships of thieno [2, 3-d] …
exerting pharmacological potential in different aspects. They are known to play a crucial role
in various disease conditions. Thieno [2, 3-d] pyrimidine derivatives have been explored for
their inhibitory activities towards various protein kinase enzymes. The present review is a
compilation on chemical synthesis and biological anticancer significance, via inhibition of
specific protein kinase enzymes, including structure–activity relationships of thieno [2, 3-d] …
Abstract
Thienopyrimidines are fused heterocyclic ring systems; structurally resemble purines, exerting pharmacological potential in different aspects. They are known to play a crucial role in various disease conditions. Thieno[2,3-d]pyrimidine derivatives have been explored for their inhibitory activities towards various protein kinase enzymes. The present review is a compilation on chemical synthesis and biological anticancer significance, via inhibition of specific protein kinase enzymes, including structure–activity relationships of thieno[2,3-d]pyrimidines derivatives reported to date.
Elsevier
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