Thiobenzothiazole-modified hydrocortisones display anti-inflammatory activity with reduced impact on islet β-cell function
Glucocorticoids signal through the glucocorticoid receptor (GR) and are administered
clinically for a variety of situations, including inflammatory disorders, specific cancers,
rheumatoid arthritis, and organ/tissue transplantation. However, glucocorticoid therapy is
also associated with additional complications, including steroid-induced diabetes. We
hypothesized that modification of the steroid backbone is one strategy to enhance the
therapeutic potential of GR activation. Toward this goal, two commercially unavailable …
clinically for a variety of situations, including inflammatory disorders, specific cancers,
rheumatoid arthritis, and organ/tissue transplantation. However, glucocorticoid therapy is
also associated with additional complications, including steroid-induced diabetes. We
hypothesized that modification of the steroid backbone is one strategy to enhance the
therapeutic potential of GR activation. Toward this goal, two commercially unavailable …
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