Thymoquinone attenuates Doxorubicin-induced nephrotoxicity in rats: Role of Nrf2 and NOX4
NM Elsherbiny, M El-Sherbiny - Chemico-biological interactions, 2014 - Elsevier
Doxorubicin (DOX) is a chemotherapeutic drug widely used for the treatment of various
neoplastic conditions. However, its application is limited because of its toxic effects in many
organs. Nephrotoxicity is a serious effect of DOX. The aim of this study was to determine the
protective effect of thymoquinone (TQ), a predominant bioactive constituent of Nigella sativa
oil, with well documented potent anti-oxidative and anti-inflammatory effects. Male Sprague
Dawley rats received DOX (3.5 mg/kg twice weekly) with or without TQ (50 mg/kg/day, oral …
neoplastic conditions. However, its application is limited because of its toxic effects in many
organs. Nephrotoxicity is a serious effect of DOX. The aim of this study was to determine the
protective effect of thymoquinone (TQ), a predominant bioactive constituent of Nigella sativa
oil, with well documented potent anti-oxidative and anti-inflammatory effects. Male Sprague
Dawley rats received DOX (3.5 mg/kg twice weekly) with or without TQ (50 mg/kg/day, oral …
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