Thyroid hormones (THs) l-thyroxine and l-triiodothyronine, primarily known as metabolism
regulators, are tyrosine-derived hormones produced by the thyroid gland. They play an
essential role in normal central nervous system development and physiological function. By
binding to nuclear receptors and modulating gene expression, THs influence neuronal
migration, differentiation, myelination, synaptogenesis and neurogenesis in developing and
adult brains. Any uncorrected THs supply deficiency in early life may result in irreversible …

Thyroid hormones (THs) L-thyroxine and L-triiodothyronine, primarily known as metabolism
regulators, are tyrosine-derived hormones produced by the thyroid gland. They play an
essential role in normal central nervous system development andphysiological function. By
binding to nuclear receptors and modulating gene expression, THs influence neuronal
migration, differentiation, myelination, synaptogenesis and neurogenesis in developing and
adult brains. Any uncorrected THs supply deficiency in early life may result inirreversible …