We present experimental results obtained with a two-dimensional segmented cell with reference electrodes along the gas channels, used to record local anode and cathode potentials. Aging protocols consisting of repeated dead-ended anode operation sequences (with anode outlet closed) were performed to assess the impact of hydrogen starvation on the local fuel cell performance. We observed strong local cathode potential excursions, as well as nonuniform ElectroChemical Surface Area (ECSA) losses and performance degradation along the cell area. The damage was more pronounced in the regions suffering the longest from fuel starvation: ie close to the anode outlet.