Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function

B Popović, BP Nicolet, A Guislain, S Engels… - Cell reports, 2023 - cell.com
… present the first comprehensive analysis of RBP-mediated regulation of T cell effector function,
and we reveal the potential of RBP modulation in defining T cell responses to target cells. …

[PDF][PDF] Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function

A ZC3HAV - scholarlypublications …
… In conclusion, the four tested RBPs regulate cytokine production in human T cells in an
RBP-… of cytokine production (Figure S3F). ZFP36L1 destabilizes cytokine mRNA in T cells To …

Regulation of IFN‐γ production by ZFP36L2 in T cells is timedependent

ND Zandhuis, A Guislain, A Popalzij… - European Journal of …, 2024 - Wiley Online Library
… of cytokine production are defined by posttranscriptional … Posttranscriptional regulation by
RNA-binding proteins (RBPs) … control its RNA binding activity and regulatory function at early …

The RNABinding Protein KSRP Modulates Cytokine Expression of CD4+ T Cells

R Käfer, L Schmidtke, K Schrick… - Journal of …, 2019 - Wiley Online Library
… pattern, which determines the function of the cell in immune … in mRNA expression levels
were also time dependent and … After several washing steps, the bound proteins were eluted …

[HTML][HTML] Emerging roles for RNA-binding proteins in T lymphocytes

S Monticelli - Immunology letters, 2022 - Elsevier
… transcripts and enhanced cytokine production [54]. A … proteins was recently defined, that
is different from their RNA … led to enhanced T cell effector responses and autoimmunity. …

ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasis.

M Turner, B Sáenz-Narciso, S Bell, L Matheson… - 2024 - researchsquare.com
… by resting T cells and represses cytokine production by memory T cells 50 12 and … Time-dependent
regulation of cytokine production by RNA 741 binding proteins defines T cell effector

Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation

…, C Conrad, M Xu, L Kifinger, T Ito-Kureha… - Nature …, 2021 - nature.com
T cell proteins by utilizing global RNA interactome capture (… parts of the cell independent
of RNA binding. Increasing the … was 4.5 ppm after time-dependent mass calibration and …

Regulation of IFNgamma production by ZFP36L2 in T cells is context-dependent

ND Zandhuis, A Guislain, A Popalzij, S Engels… - bioRxiv, 2024 - biorxiv.org
… may outcompete, or control its RNA binding activity and regulatory function at early …
Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector

Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR

C Stellato, MM Gubin, JD Magee, X Fang… - The Journal of …, 2011 - journals.aai.org
… human T cells determines global, coordinate changes of mRNA … also be due to cell type-
and time-dependent toxicity related to … of nonviable T cells that do not process RNA efficiently. …

CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation

…, I Vermeire, T Schalley, M Planque, T van Brussel… - Cell Reports, 2022 - cell.com
… a differential time-dependent reliance of activating T cells on … proliferation and cytokine
production. Disrupting the ability of … in modulating T cell differentiation and effector function, which …