Time-resolved diffuse optical tomography using a modified generalized pulse spectrum technique

F Gao, H Zhao, Y Tanikawa… - Ieice Transactions on …, 2002 - search.ieice.org
F Gao, H Zhao, Y Tanikawa, Y YAMADA
Ieice Transactions on information and systems, 2002search.ieice.org
Generalized Pulse Spectrum Technique (GPST) is a method to solve the inverse problems
of wave-propagation and diffusion-dominated phenomena, and therefore has been
popularly applied in image reconstruction of time-resolved diffuse optical tomography. With
a standard GPST for simultaneous reconstruction of absorption and scattering coefficients,
the products of the gradients of the Green's function and the photon-density flux, based on
the photon-diffusion equation, are required to calculate the diffusion-related Jacobian matrix …
Generalized Pulse Spectrum Technique (GPST) is a method to solve the inverse problems of wave-propagation and diffusion-dominated phenomena, and therefore has been popularly applied in image reconstruction of time-resolved diffuse optical tomography. With a standard GPST for simultaneous reconstruction of absorption and scattering coefficients, the products of the gradients of the Green's function and the photon-density flux, based on the photon-diffusion equation, are required to calculate the diffusion-related Jacobian matrix. The adversities are of two-folds: time-consuming and singular in the field near the source. The latter causes a severe insensitivity of the algorithm to the scattering changes deep inside tissue. To cope with the above difficulties, we propose in this paper a modified GPST algorithm that only involves the Green's function and the photon-density flux themselves in the scattering-related matrix. Our simulated and experimental reconstructions show that the modified algorithm can significantly improve the quality of scattering image and accelerate the reconstruction process, without an evident degradation in absorption image.
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