Titrating the effects of mitochondrial complex I impairment in the cell physiology
A Barrientos, CT Moraes - Journal of Biological Chemistry, 1999 - ASBMB
The mitochondrial oxidative phosphorylation system consists of five multimeric enzymes
(complexes I–V). NADH dehydrogenase or complex I (CI) is affected in most of the
mitochondrial diseases and in some neurodegenerative disorders. We have studied the
physiological consequences of a partial CI inhibition at the cellular level. We used a genetic
model (40% CI-inhibited human-ape xenomitochondrial cybrids) and a drug-induced model
(0–100% CI-inhibited cells using different concentrations of rotenone). We observed a …
(complexes I–V). NADH dehydrogenase or complex I (CI) is affected in most of the
mitochondrial diseases and in some neurodegenerative disorders. We have studied the
physiological consequences of a partial CI inhibition at the cellular level. We used a genetic
model (40% CI-inhibited human-ape xenomitochondrial cybrids) and a drug-induced model
(0–100% CI-inhibited cells using different concentrations of rotenone). We observed a …
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