For cancer therapy, viruses have been utilized as excellent delivery vehicles because of
their facile transfection efficiency in their host cells. However, their inherent immunogenicity
has become the major obstacle for their translation into approved pharmaceuticals. Herein,
we utilized rodlike plant virus, tobacco mosaic virus (TMV), which is nontoxic to mammals
and mainly infects tobacco species, as anticancer nanorod-drug vector for cancer therapy
study. Doxorubicin (DOX) was installed in the inner cavity of TMV by hydrazone bond, which …