[HTML][HTML] Toll-like receptor 4 polymorphisms predispose to cutaneous leishmaniasis
S Ajdary, MM Ghamilouie, MH Alimohammadian… - Microbes and …, 2011 - Elsevier
The clinical spectrum of cutaneous leishmaniasis (CL) is extremely variable. Studies in
experimental leishmaniasis have revealed a role for TLR4 in control of infection. In the
present study the associations between TLR4 mutations (Asp299Gly and Thr399Ile) with
outcome of CL have been investigated. Genotyping for Asp299Gly and Thr399Ile was
performed in patients with chronic (N= 22) and acute (N= 61) CL, asymptomatic (N= 45) and
healthy leishmanin skin test negative individuals (N= 75). The results showed the frequency …
experimental leishmaniasis have revealed a role for TLR4 in control of infection. In the
present study the associations between TLR4 mutations (Asp299Gly and Thr399Ile) with
outcome of CL have been investigated. Genotyping for Asp299Gly and Thr399Ile was
performed in patients with chronic (N= 22) and acute (N= 61) CL, asymptomatic (N= 45) and
healthy leishmanin skin test negative individuals (N= 75). The results showed the frequency …
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