TosR-mediated regulation of adhesins and biofilm formation in uropathogenic Escherichia coli
Uropathogenic Escherichia coli strains utilize a variety of adherence factors that assist in
colonization of the host urinary tract. TosA (t ype o ne s ecretion A) is a nonfimbrial adhesin
that is predominately expressed during murine urinary tract infection (UTI), binds to kidney
epithelial cells, and promotes survival during invasive infections. The tosRCBDAEF operon
encodes the secretory machinery necessary for TosA localization to the E. coli cell surface,
as well as the transcriptional regulator TosR. TosR binds upstream of the tos operon and in …
colonization of the host urinary tract. TosA (t ype o ne s ecretion A) is a nonfimbrial adhesin
that is predominately expressed during murine urinary tract infection (UTI), binds to kidney
epithelial cells, and promotes survival during invasive infections. The tosRCBDAEF operon
encodes the secretory machinery necessary for TosA localization to the E. coli cell surface,
as well as the transcriptional regulator TosR. TosR binds upstream of the tos operon and in …
[引用][C] TosR-mediated regulation of adhesins and biofilm formation in uropathogenic Escherichia coli. mSphere 2018; 3: e00222–18
CL Luterbach, VS Forsyth, MD Ergstrom, HLT Mobley - Crossref Search Google Scholar …
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