Rapamycin (l)* 1· 2 is a novel, naturally occurring substance, with potent antibiotic, cytotoxic,
and immunosuppressive activity. Isolated from Streptomyces hygroscopicus found in an …

… ozonolysis in our avermectin B 1a total synthesis project28 influenced our efforts at cleaving
… highly valuable in our rapamycin synthesis program (Scheme 4). Synthesis of epoxide 6: In …

Details of the total synthesis of rapamycin (1) are reported. The synthesis required the preparation
of intermediates 4 – 9 in nonracemic form; key coupling reactions included a chromium…

… the formation of the rapamycin macrocycle by employing a transannular catechol-templated
Dieckmann-like reaction that was used with success in our recent synthesis of the related …

… in place of the ketone at C32 of rapamycin.6 We reasoned that the C32-(S')-… total synthesis
of rapamycin that follows from these considerations.8 Our reported synthesis of the rapamycin …

… The total synthesis of rapamycin was first reported by Nicolaou et … In the case of rapamycin,
we recently described investigations … Herein, we disclose the total synthesis of rapamycin …

… Herein we report the application of the former strategem to the total syntheses of rapamycin
(1) and demethoxyrapamycin (2). This first successful route to 2 confirmed the proposed …

… We have devised and executed a unified, highly convergent total synthesis of (−)-rapamycin
(1) and (−)-27-demethoxyrapamycin (2), confirming the latter structure. For rapamycin, the …

A total synthesis of the potent, naturally occurring immunomodulators (−)-rapamycin (1) and
(−)-27-demethoxyrapamycin (2) has been achieved via a unified, highly convergent …

… Our goal was to synthesize rapamycin via application of the chemistry developed in these
laboratories from the … A total synthesis would allow access to analogues that might be potential …