Phuket Island has globally renowned as the sea-sun-sand destination, resulting in a rapidly increasing number of arrivals reaching 10 million in 2015. Therefore, safety and security are significant to provide quality in the island tourism and to maintain its destination image. The purpose of this study was to evaluate how international tourists felt about safety and security while visiting the island, based on data collection at the Phuket International Airport during March-April, 2016. An exploratory study on tourists’ profile and their perceptions of safety and security environment were numerically and graphically summarized to gain insight into the data. Then, multivariate of analysis of variance was carried out to investigate the effects of cultural differences and destination familiarity on the safe and secured perceptions. The findings reveal that the tourists from Oceania and Europe countries felt safer with touristic activities than those from the Asian countries. The more often they visited the destination the less comfortable tourists were with the traffic and road safety on the island. A further study on potential factors associated with the perceptions toward the safe and secure environment on the island is urgently recommended.