Toward the design of smart delivery systems controlled by integrated enzyme-based biocomputing ensembles
We report herein the design of a smart delivery system in which cargo delivery from capped
mesoporous silica (MS) nanoparticles is controlled by an integrated enzyme-based “control
unit”. The system consists of Janus-type nanoparticles having opposing Au and MS faces,
functionalized with a pH-responsive β-cyclodextrin-based supramolecular nanovalve on the
MS surface and two effectors, glucose oxidase and esterase, immobilized on the Au face.
The nanodevice behaves as an enzymatic logical OR operator which is selectively fueled by …
mesoporous silica (MS) nanoparticles is controlled by an integrated enzyme-based “control
unit”. The system consists of Janus-type nanoparticles having opposing Au and MS faces,
functionalized with a pH-responsive β-cyclodextrin-based supramolecular nanovalve on the
MS surface and two effectors, glucose oxidase and esterase, immobilized on the Au face.
The nanodevice behaves as an enzymatic logical OR operator which is selectively fueled by …
[引用][C] Toward the Design of Smart Delivery Systems Controlled by Integrated Enzyme-Based Biocomputing Ensembles
D Paula, S Alfredo, G María, MR Paloma, A Elena… - 2014
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