Towards a practical Brønsted acid catalyzed and hantzsch ester mediated asymmetric reductive amination of ketones with benzylamine
Synlett, 2010•thieme-connect.com
We report the use of benzylamine as the amine component in Hantzsch ester mediated and
chiral Brønsted acid catalyzed enantioselective reductive aminations of ketones. The
method is noteworthy because the benzyl group is easily removable, and amine product
purification is achieved through Hantzsch ester oxidation product removal via basic
hydrolysis.
chiral Brønsted acid catalyzed enantioselective reductive aminations of ketones. The
method is noteworthy because the benzyl group is easily removable, and amine product
purification is achieved through Hantzsch ester oxidation product removal via basic
hydrolysis.
Abstract
We report the use of benzylamine as the amine component in Hantzsch ester mediated and chiral Brønsted acid catalyzed enantioselective reductive aminations of ketones. The method is noteworthy because the benzyl group is easily removable, and amine product purification is achieved through Hantzsch ester oxidation product removal via basic hydrolysis.
Thieme Connect以上显示的是最相近的搜索结果。 查看全部搜索结果