Since recently, it is accepted that mediation can take many forms depending on the application domains: for example, mediation can be seen as a means to deal with interoperability between legacy applications in large Information Systems in a variety of environments including Cloud or to synchronize, integrate and route data from sensor networks in pervasive applications. In this paper we present a lightweight, modular, dynamic and distributed framework called Cilia dedicated to mediation. Cilia aims at bringing an homogeneous solution to deal with mediation both in big and little systems and to ensure the seamless integration of the two systems. In this paper we demonstrate the benefits of the Cilia approach through a case study from an RFID project.