Towards understanding antimicrobial activity, cytotoxicity and the mode of action of dichapetalins A and M using in silico and in vitro studies
Abstract Dichapetalum madagascariense Poir (Dichapetalaceae) is traditionally used to
treat bacterial infections, jaundice, urethritis and viral hepatitis in Africa. Its root contains a
broad spectrum of biologically active dichapetalins. To evaluate the plant's effect on human
MCF-7 cells and its' antibacterial and antiparasitic potentials, we isolated and identified the
known dichapetalins A and M from the roots. Both dichapetalins were tested on six bacterial
strains (Shigella flexneri, Bacillus cereus, Salmonella paratyphi B, Listeria monocytogenes …
treat bacterial infections, jaundice, urethritis and viral hepatitis in Africa. Its root contains a
broad spectrum of biologically active dichapetalins. To evaluate the plant's effect on human
MCF-7 cells and its' antibacterial and antiparasitic potentials, we isolated and identified the
known dichapetalins A and M from the roots. Both dichapetalins were tested on six bacterial
strains (Shigella flexneri, Bacillus cereus, Salmonella paratyphi B, Listeria monocytogenes …
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