Toxoplasma gondii infection triggers host microtubule rearrangement and organelle
recruitment around the parasite vacuole. Factors affecting initial stages of microtubule
remodeling are unknown. To illuminate the mechanism, we tested the hypothesis that the
parasite actively remodels host microtubules. Utilizing heat-killed parasites and time-lapse
analysis, we determined microtubule rearrangement requires living parasites and is time
dependent. We discovered a novel aster of microtubules (MTs) associates with the vacuole …