Derangement of glucose metabolism is a key feature of T2DM, with the liver and pancreatic
β-cells playing a key role in glucose homeostasis. In the postprandial state, glucose is
transported into hepatocytes and either metabolized to fatty acids or CO2, or stored as
glycogen. Glucose also acts as a key signal in pancreatic β-cells for regulating insulin
secretion. Because GLUT2 and GK expressed in liver and β-cells are responsible for
sensing glucose levels in the blood, studies on the regulation of these biomolecules are …

Pancreatic β-cells and the liver play a key role in glucose homeostasis. After a meal or in a
state of hyperglycemia, glucose is transported into the β-cells or hepatocytes where it is
metabolized. In the β-cells, glucose is metabolized to increase the ATP: ADP ratio, resulting
in the secretion of insulin stored in the vesicle. In the hepatocytes, glucose is metabolized to
CO2, fatty acids or stored as glycogen. In these cells, solute carrier family 2 (SLC2A2) and
glucokinase play a key role in sensing and uptaking glucose. Dysfunction of these proteins …