Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein α and hepatocyte nuclear factor-3γ
Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more than 50% of
currently used therapeutic drugs, yet the mechanisms that control CYP3A4 basal expression
in liver are poorly understood. Several putative binding sites for CCAAT/enhancer-binding
protein (C/EBP) and hepatic nuclear factor 3 (HNF-3) were found by computer analysis in
CYP3A4 promoter. The use of reporter gene assays, electrophoretic mobility shift assays,
and site-directed mutagenesis revealed that one proximal and two distal C/EBPα binding …
currently used therapeutic drugs, yet the mechanisms that control CYP3A4 basal expression
in liver are poorly understood. Several putative binding sites for CCAAT/enhancer-binding
protein (C/EBP) and hepatic nuclear factor 3 (HNF-3) were found by computer analysis in
CYP3A4 promoter. The use of reporter gene assays, electrophoretic mobility shift assays,
and site-directed mutagenesis revealed that one proximal and two distal C/EBPα binding …
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