Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods
Many reprogramming methods can generate human induced pluripotent stem cells (hiPSCs)
that closely resemble human embryonic stem cells (hESCs). This has led to assessments of
how similar hiPSCs are to hESCs, by evaluating differences in gene expression, epigenetic
marks and differentiation potential. However, all previous studies were performed using
hiPSCs acquired from different laboratories, passage numbers, culturing conditions, genetic
backgrounds and reprogramming methods, all of which may contribute to the reported …
that closely resemble human embryonic stem cells (hESCs). This has led to assessments of
how similar hiPSCs are to hESCs, by evaluating differences in gene expression, epigenetic
marks and differentiation potential. However, all previous studies were performed using
hiPSCs acquired from different laboratories, passage numbers, culturing conditions, genetic
backgrounds and reprogramming methods, all of which may contribute to the reported …
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