… The goals of this phase1trial were to assess the safety … neuralstemcells in the spinalcord, and to examine the use of immunosuppression in ALS subjects, using a risk escalation study …
…, ALS-NSCs Trial Study Group - Stem cells …, 2019 - academic.oup.com
… of more homogenous future phaseI, II, and III … : Our study reached the primary endpoint, and our results underscore that micro-transplantation of cells into the human anterior spinalcord …
…, J Glass, G Sorarù, NM Boulis, AL Vescovi - Journal of translational …, 2015 - Springer
… We transplanted GMP-grade, fetal human neuralstemcells … horns of the spinalcord to test for the safety of both cells and … study on six patients with ALS shows that transplantation of …
E Curtis, JR Martin, B Gabel, N Sidhu, TK Rzesiewicz… - Cell stem cell, 2018 - cell.com
… of human-spinal-cord-derivedneuralstemcell (NSI-566) transplantation for the treatment of chronic spinalcord injury (SCI). In this clinical … for ALS: Analysis of phase1 and 2trials. …
RH Baloh, JP Johnson, P Avalos, P Allred… - Nature medicine, 2022 - nature.com
… This study shows that one administration of engineered neural progenitors can provide … cells and GDNF delivery to the ALS patient spinalcord for up to 42 months post-transplantation. …
… in the prospect of transplantingstemcells into the nervous system for the … spinalcord‐derived stemcells (HSSCs) into the lumbar … This is a phaseIstudy, focusing on the issues of safety …
… spinalcordneuralprogenitorcells and the pipeline starting from preclinical studies to the designs of phaseI and IIa clinical trials … Although the phaseIstudy was not designed to …
J Riley, T Federici, M Polak, C Kelly, J Glass… - …, 2012 - journals.lww.com
… Each injection deposited 100 000 neuralstemcellsderived from a fetal spinalcord. Twelve patients … This study uses a methodology that has been carefully developed and validated as …