Transposon insertion profiling by sequencing (TIPseq) for mapping LINE-1 insertions in the human genome
JP Steranka, Z Tang, M Grivainis, CRL Huang… - Mobile DNA, 2019 - Springer
Background Transposable elements make up a significant portion of the human genome.
Accurately locating these mobile DNAs is vital to understand their role as a source of
structural variation and somatic mutation. To this end, laboratories have developed
strategies to selectively amplify or otherwise enrich transposable element insertion sites in
genomic DNA. Results Here we describe a technique, Transposon Insertion Profiling by
sequencing (TIPseq), to map Long INterspersed Element 1 (LINE-1, L1) retrotransposon …
Accurately locating these mobile DNAs is vital to understand their role as a source of
structural variation and somatic mutation. To this end, laboratories have developed
strategies to selectively amplify or otherwise enrich transposable element insertion sites in
genomic DNA. Results Here we describe a technique, Transposon Insertion Profiling by
sequencing (TIPseq), to map Long INterspersed Element 1 (LINE-1, L1) retrotransposon …
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