[HTML][HTML] Treatment-refractory cutaneous Rosai–Dorfman disease responsive to oral methotrexate and topical trametinib
JAAD Case Reports, 2023•Elsevier
… Some patients, however, may be refractory to surgery, or further excision can be
associated with significant morbidity in cosmetically sensitive areas. Here, we present a
case of progressive, ulcerating CRDD responsive to the combination of methotrexate and a
topical MEK inhibitor, added to intralesional triamcinolone. … We report a novel case of
CRDD that recurred following surgical excision and was refractory to numerous lines of
therapy, including ILTAC monotherapy, but ultimately responded to the addition of topical …
associated with significant morbidity in cosmetically sensitive areas. Here, we present a
case of progressive, ulcerating CRDD responsive to the combination of methotrexate and a
topical MEK inhibitor, added to intralesional triamcinolone. … We report a novel case of
CRDD that recurred following surgical excision and was refractory to numerous lines of
therapy, including ILTAC monotherapy, but ultimately responded to the addition of topical …
Discussion
We report a novel case of CRDD that recurred following surgical excision and was refractory to numerous lines of therapy, including ILTAC monotherapy, but ultimately responded to the addition of topical MEK inhibition and methotrexate.
Elsevier
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