… allowing the formation of tripartite RND efflux pumps as characterized by native … tripartite
RND efflux systems were incorporated into a lipid membrane ND and were further assembled …

… RND-family multidrug efflux pump MexXY requires the presence of Mg 2+ in the medium for
its function [38]. The pumping … component classes of the tripartite assembly are known, and it …

… In Gram-negative bacteria, some of the pumps comprise tripartite assemblies that actively
transport drugs and other harmful compounds across the cell envelope. We describe recent …

… aeruginosa expel drugs via tripartite multidrug efflux pumps spanning both inner and outer
membranes and the intervening periplasm. In these pumps a periplasmic adaptor protein …

… components has shed new light on the mechanism by which the tripartite efflux pumps
extrude drugs. This new information will be critical in developing inhibitors against MDR …

… Schematic drawing of tripartite RND multidrug efflux system AcrAB–TolC of the Gram-negative
bacterium Escherichia coli (courtesy of Andrea Eberle, Heinrich-Heine-Universität …

… that the tripartite architecture is not completely limited to RND pumps. In E. coli, an MFS efflux
pump EmrB is known to form a tripartite … Hypothetical models of the tripartite assembly were …

… These include insights into the molecular determinants for their polyspecificity, the mechanisms
for substrate transport and those behind inhibition, the assembly of tripartite assembly …

… Multidrug efflux transporters of the resistance-nodulation-cell division (RND) superfamily are
one of the main causes of multidrug … generally occur as tripartite efflux complexes that span …

… class of bacterial efflux pumps–the tripartite Resistance-Nodulation-Division (RND) family
that is … These findings thus underscore the critical role of complete tripartite pump assembly in …