Triplex-Inspector: an analysis tool for triplex-mediated targeting of genomic loci
Bioinformatics, 2013•academic.oup.com
At the heart of many modern biotechnological and therapeutic applications lies the need to
target specific genomic loci with pinpoint accuracy. Although landmark experiments
demonstrate technological maturity in manufacturing and delivering genetic material, the
genomic sequence analysis to find suitable targets lags behind. We provide a computational
aid for the sophisticated design of sequence-specific ligands and selection of appropriate
targets, taking gene location and genomic architecture into account. Availability: Source …
target specific genomic loci with pinpoint accuracy. Although landmark experiments
demonstrate technological maturity in manufacturing and delivering genetic material, the
genomic sequence analysis to find suitable targets lags behind. We provide a computational
aid for the sophisticated design of sequence-specific ligands and selection of appropriate
targets, taking gene location and genomic architecture into account. Availability: Source …
Abstract
Summary: At the heart of many modern biotechnological and therapeutic applications lies the need to target specific genomic loci with pinpoint accuracy. Although landmark experiments demonstrate technological maturity in manufacturing and delivering genetic material, the genomic sequence analysis to find suitable targets lags behind. We provide a computational aid for the sophisticated design of sequence-specific ligands and selection of appropriate targets, taking gene location and genomic architecture into account.
Availability: Source code and binaries are downloadable from www.bioinformatics.org.au/triplexator/inspector.
Contact: t.bailey@uq.edu.au
Supplementary information: Supplementary data are available at Bioinformatics online.
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