Turn-on fluorescent sensors for Cu-rich amyloid β peptide aggregates
Protein misfolding and metal dishomeostasis are two key pathological factors of Alzheimer's
disease. Previous studies have shown that Cu-mediated amyloid β (Aβ) peptide aggregation
leads to the formation of neurotoxic Aβ oligomers. Herein, we report a series of picolinic acid-
based Cu-activatable sensors, which can be used for the fluorescence imaging of Cu-rich
Aβ aggregates.
disease. Previous studies have shown that Cu-mediated amyloid β (Aβ) peptide aggregation
leads to the formation of neurotoxic Aβ oligomers. Herein, we report a series of picolinic acid-
based Cu-activatable sensors, which can be used for the fluorescence imaging of Cu-rich
Aβ aggregates.
Protein misfolding and metal dishomeostasis are two key pathological factors of Alzheimer's disease. Previous studies have shown that Cu-mediated amyloid β (Aβ) peptide aggregation leads to the formation of neurotoxic Aβ oligomers. Herein, we report a series of picolinic acid-based Cu-activatable sensors, which can be used for the fluorescence imaging of Cu-rich Aβ aggregates.
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